Publications

Connacher RP, Roden RT, Huang KL, Korte AJ, Yeruva S, Dittbenner N, DesMarais AJ, Weidmann CA, Randall TA, Williams J, Hall TM, Wagner EJ, Goldstrohm AC. "The TRIM-NHL RNA-Binding protein Brain Tumor coordinately regulates expression of the glycolitic pathway and vacuolar ATPase compex." Nucleic Acids Res. 2024 https://doi.org/10.1093/nar/gkae810 

Hall I, Zablock K, Sobetski R, Weidmann CA, Keane SC. "Functional Validation of SAM Riboswitch Element A from Listeria monocytogenes." Biochemistry. 2024 https://doi.org/10.1021/acs.biochem.4c00247 

Hall I, Zablock K, Sobetski R, Weidmann CA, Keane SC. "Functional Validation of SAM Riboswitch Element A from Listeria monocytogenes." bioRxiv. 2024 https://doi.org/10.1101/2024.05.28.596223  

Hatfield BM, Weidmann CA, Weeks KM. "Measuring Proximity-Mediated Function of mRNA Regulatory Proteins by Engineered Tethering." Methods in Molecular Biology. 2024 https://doi-org/10.1007/978-1-0716-3481-3_9 PDF 

Khan A, Metts JM, Collins LC, Mills CA, Li K, Brademeyer AL, Bowman BM, Major MB, Aubé J, Herring LE, Davis IJ, Strahl BD. "SETD2 maintains nuclear lamina stability to safeguard the genome." bioRxiv. 2023 https://doi-org/10.1101/2023.09.28.560032 PDF 

Paiboonrungruang C, Xiong Z, Lamson D, Li Y, Bowman BM, Chembo J, Huang C, Li J, Livingston EW, Frank JE, Chen V, Li Y, Weissman BE, Yuan H, Williams KP, Major MB, Chen Xiaoxin. "Small molecule screen identifies pyrimethamine as an inhibitor of NRF2-driven esophageal hyperplasia." Redox Biology. 2023 https://doi.org/10.1016/j.redox.2023.102901 PDF 

Mustoe AM, Weidmann CA, Weeks KM. "Single-Molecule Correlated Chemical Probing: A Revolution in RNA Structure Analysis." Acc Chem Res. 2023 https://pubs.acs.org/doi/10.1021/acs.accounts.2c00782 PDF 

Monroy-Eklund A, Taylor C, Weidmann CA, Burch C, Laederach A. "Structural Analysis of MALAT1 long non-coding RNA in cells and in evolution." RNA. 2023 https://doi.org/10.1261/rna.079388.122 PDF 

Grayeski PJ, Weidmann CA, Kumar J, Lackey L, Mustoe AM, Busan S, Laederach A, Weeks KM. "Global 5'-UTR RNA structure regulates translation of a SERPINA1 mRNA." Nucleic Acids Research. 2022 https://doi.org/10.1093/nar/gkac739 PDF 

Hamad SH, Montgomery SA, Simon JM, Bowman BM, Spainhower KB, Murphy RM, Knudsen ES, Fenton SE, Randell SH, Holt JR, Hayes DN, Witkiewicz KA, Oliver TG, Major MB, Weissmann BE. "TP53, CDKN2A/P16, and NFE2L2/NRF2 regulate the incidence of pure- and combined-small cell lung cancer in mice." Oncogene 2022 https://doi.org/10.1038/s41388-022-02348-0 PDF 

Olson SW, Turner AMW, Arney JW, Saleem I, Weidmann CA, Margolis DM, Weeks KM, Mustoe AM. "Discovery of a large-scale, cell-state-responsive allosteric switch in the 7SK RNA using DANCE-MaP." Molecular Cell. 2022 https://doi.org/10.1016/j.molcel.2022.02.009 PDF 

Agajanian MJ, Potjewyd FM, Bowman BM, Solomon S, LaPak KM, Bhatt DP, Smith JL, Goldfarb D, Axtman AD, Major MB. "Protein proximity networks and functional evaluation of the casein kinase 1 gamma family reveal unique roles for CK1y3 in WNT signaling." JBC. 2022  https://doi.org/10.1016/j.jbc.2022.101986 PDF 

Przanowska RK, Weidmann CA, Saha S, Cichewicz MA, Jensen KN, Przanowski P, Irving PS, Janes KA, Guertin MJ,  Weeks KM, Dutta A. “Distinct MUNC lncRNA structural domains regulate transcription of different promyogenic factors.” Cell Reports. 2022. https://doi.org/10.1016/j.celrep.2022.110361 PDF 

Olson SW, Turner AW, Arney JW, Saleem I, Weidmann CA, Margolis DM, Weeks KM, Mustoe AM. “Large-scale allosteric switch in the 7SK RNA regulates transcription in response to growth and stress.” bioRxiv. 2021 https://doi.org/10.1101/2021.09.16.460563 PDF  

Przanowska RK, Weidmann CA, Saha S, Cichewicz MA, Jensen KN, Przanowski P, Irving PS, Guertin MJ,  Weeks KM, Dutta A. “Distinct MUNC lncRNA structural domains regulate transcription of different promyogenic factors.” bioRxiv. 2021 https://doi.org/10.1101/2021.06.22.449443 PDF 

Weidmann CA, Mustoe AM, Jariwala PB, Calabrese JM, Weeks KM. “Analysis of RNA-protein networks with RNP-MaP defines functional hubs on RNA.” Nat. Biotechnol. 2021 https://doi.org/10.1038/s41587-020-0709-7 PDF 

Iserman C*, Roden CA*, Boerneke MA, Sealfon RSG, McLaughlin GA, Jungreis I, Fritch EJ, Hou YJ, Ekena J, Weidmann CA, Theesfeld CL, Kellis M, Troyanskaya OG, Baric RS, Sheahan TP, Weeks KM, Gladfelter AS. “Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid.” Mol. Cell. 2020 https://doi.org/10.1016/j.molcel.2020.11.041 PDF 

Harrison EB, Porrello A, Bowman BM, Belanger AR, Yacovone G, Azam SH, Windham IA, Ghosh SK, Wang M, Mckenzie N, Waugh TA, Van Swearingen AED, Cohen SM, Allen DG, Goodwin TJ, Mascenik T, Bear JE, Cohen S, Randell SH, Massion PP, Major MB, Huang L, Pecot CV. “A Circle RNA Regulatory Axis Promotes Lung Squamous Metastasis via CDR1-Mediated Regulation of Golgi Trafficking.” Cancer Res. 2020 https://doi.org/10.1158/0008-5472.can-20-1162 PDF 

Bowman BM, Montgomery SA, Schrank TP, Simon JM, Ptacek TS, Tamir TY, Mulvaney KM, Weir SJ, Nguyen TT, Murphy RM, Makowski L, Hayes DN, Chen LZ, Randell SH, Weissman BE, Major MB. "A conditional mouse expressing an activating mutation in NRF2 displays hyperplasia of the upper gastroinestinal tract and decreased white adipose tissue." Journal of Pathology. 2020 https://doi.org/10.1002/path.5504 PDF 

Tamir TY, Bowman BM, Agajanian MJ, Goldfarb D, Schrank TP, Stohrer T, Hale AE, Siesser PF, Weir SJ, Murphy RM, LaPak KM, Weissman BE, Moorman NJ, Major MB. "Gain-of-function genetic screen of the kinome reveals BRSK2 as an inhibitor of the NRF2 transcription factor." Journal of Cell Science. 2020 https://doi.org/10.1242/jcs.241356 PDF 

Schmidt K*, Weidmann CA*, Hilimire TA, Yee E, Hatfield BM, Schneekloth Jr. JS, Weeks KM, Novina C. “Targeting the oncogenic long non-coding RNA SLNCR1 by blocking its sequence-specific binding to the androgen receptor.” Cell Rep. 2020  https://doi.org/10.1016/j.celrep.2019.12.011 PDF 

Giannetti, CA, Busan S, Weidmann CA, Weeks KM. “SHAPE probing reveals human ribosomal RNAs are largely unfolded in solution.” Biochemistry. 2019 https://doi.org/10.1021/acs.biochem.9b00076 PDF 

Busan S*, Weidmann CA*, Sengupta A, Weeks KM. “Guidelines for SHAPE reagent choice and detection strategy for RNA structure probing studies.” Biochemistry. 2019 https://doi.org/10.1021/acs.biochem.8b01218 PDF 

Langdon EM, Qiu Y, Ghanbari Niaki A, McLaughlin GA, Weidmann CA, Gerbich TM, Smith JA, Crutchley JM, Termini CM, Weeks KM, Myong S, Gladfelter AS. “mRNA structure determines specificity of a polyQ-driven phase separation.” Science. 2018 https://doi.org/10.1126/science.aar7432 PDF 

Bohn JA, Van Etten JL, Schagat TL, Bowman BM, McEachin RC, Freddolino PL, Goldstrohm AC. “Identification of diverse target RNAs that are functionally regulated by human Pumilio proteins.” Nucleic Acids Res. 2018 https://doi.org/10.1093/nar/gkx1120 PDF 

Arvola RM, Weidmann CA, Tanaka Hall TM, Goldstrohm AC. “Combinatorial control of messenger RNAs by Pumilio, Nanos and Brain Tumor Proteins.” RNA Biol. 2017 https://doi.org/10.1080/15476286.2017.1306168 PDF 

Lou TF, Weidmann CA, Killingsworth J, Tanaka Hall TM, Goldstrohm AC, Campbell ZT. “Integrated analysis of RNA-binding protein complexes using in vitro selection and high-throughput sequencing and sequence specificity landscapes (SEQRS).” Methods. 2017 https://doi.org/10.1016/j.ymeth.2016.10.001 PDF 

Weidmann CA*, Mustoe AM*, and Weeks KM. “Direct Duplex Detection: An Emerging Tool in the RNA Structure Analysis Toolbox.” Trends Biochem Sci. 2016 https://doi.org/10.1016/j.tibs.2016.07.001 PDF 

Weidmann CA*, Qiu C*, Arvola RM, Lou T, Killingsworth J, Campbell ZT, Hall TM, Goldstrohm AC. “Drosophila Nanos acts as a molecular clamp that modulates the RNA-binding and repression activities of Pumilio.” eLife. 2016 https://doi.org/10.7554/elife.17096 PDF 

Bowman BM, Sebolt KA, Hoff BA, Boes JL, Daniels DL, Heist KA, Galbán CJ, Patel RM, Zhang J, Beer DG, Ross BD, Rehemtualla A, Galbán S. "Phosphorylation of FADD by CK1a promotes KRASG12D-induced lung cancer." Science Signaling. 2015 https://doi.org/10.1126/scisignal.2005607 PDF 

Weidmann CA, Raynard NA, Blewett NH, Van Etten J, and Goldstrohm AC. “The RNA binding domain of Pumilio antagonizes poly-adenosine binding protein and accelerates deadenylation.” RNA. 2014 https://doi.org/10.1261/rna.046029.114  PDF 

Galbán S, Jeon YH, Bowman BM, Stevenson J, Sebolt KA, Sharkey LM, Lafferty M, Hoff BA, Butler BL, Wigdal SS, Binkowski BF, Otto P, Zimmerman K, Vidugiris G, Encell LP, Fan F, Wood KV, Galbán CJ, Ross BD, Rehemtulla A. "Imaging Proteolytic Activity in Live Cells and Animal Models." PLoS One. 2013 https://doi.org/10.1371/journal.pone.0066248 PDF 

Wang H, Galbán S, Wu R, Bowman BM, Witte A, Vetter K, Galbán CJ, Ross BD, Cho KR, Rehemtualla A. "Molecular Imaging Reveals a Role for AKT in Resistance to Cisplatin for Ovarian Endometroid Adenocarcinoma." Clinical Cancer Research. 2013 https://doi.org/10.1158/1078-0432.CCR-12-2380 PDF 

Van Etten J, Schagat T, Hrit J, Weidmann CA, and Goldstrohm AC.“Human Pumilio proteins recruit multiple deadenylases to efficiently repress messenger RNAs.” J. Biol. Chem. 2012 https://doi.org/10.1074/jbc.m112.373522 PDF 

Weidmann CA and Goldstrohm A. 2012. “Drosophila Pumilio protein contains multiple autonomous repression domains that regulate mRNAs independently of Nanos and Brain Tumor” Mol. Cell. Biol. January; 32(2): 527-540. PMID: 22064486 PMCID: PMC3255780; doi: https://doi.org/10.1128/mcb.06052-11 PDF