We are advancing new chemical probing, sequencing, and bioinformatics technologies that will reveal and define functional RNA-protein interaction networks inside cells. We are also interested in developing technologies to target these networks. (R01GM155542) 

We apply multi-omics approaches to understand long noncoding RNAs that promote cancer progression and metastasis (NCI K22 CA262349), especially in non-small cell lung cancer. Image adapted from publication here. 

We are defining substrate specificities of RNA-modifying enzymes inside cells and applying multi-omics and reporter assays to understand these molecular switches.

We are defining messenger RNA domains that determine localization and promote defined protein niches within the cell by chemical probing, microscopy, and reporter assays.