Projects are focused on understanding how noncoding RNAs accomplish a myriad of biological feats.
The fundamental principles of RNA-protein interaction networks inform their therapeutic targeting.
CELL RNP NEtworks
CELL RNP NEtworks
We are advancing new chemical probing, sequencing, and bioinformatics technologies that will reveal and define functional RNA-protein interaction networks and RNA structures in cells.
METASTATIC LNCRNAs
METASTATIC LNCRNAs
We are applying multi-omics approaches to understand how lncRNA-protein interaction networks of MALAT1 promote lung cancer metastasis (NCI K22 CA262349). Image adapted from publication here.
RNA Modifications
RNA Modifications
We are defining the in-cell substrate specificity of RNA-modifying enzymes and applying multi-omics to understand these molecular switches.
